Convulsions and hyperglycaemia associated with nalidixic acid.

نویسندگان

  • A G Fraser
  • A D Harrower
چکیده

Hyperglycaemia and convulsions in patients taking nalidixic acid are usually associated with overdosage of the drug or an underlying epileptic tendency.' :1 Nalidixic acid may also interfere with biochemical determinations of plasma and urinary glucose, giving falsepositive results. We describe an otherwise healthy patient who had convulsions and hyperglycaemia (confirmed by a glucose-specific method4) while on a therapeutic dose of the drug.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Structure-epileptogenicity relationship of quinolones with special reference to their interaction with gamma-aminobutyric acid receptor sites.

The relationship between the chemical structure and epileptogenic activity of quinolones was investigated. When the quinolones were administered intravenously to mice concomitantly with oral biphenylacetic acid, a major metabolite of the nonsteroidal antiinflammatory drug fenbufen, enoxacin, norfloxacin, ciprofloxacin, and pipemidic acid, which have an unsubstituted piperazine moiety at the 7 p...

متن کامل

بررسی مقایسه‌ای اثر بخشی دو داروی نالیدیکسیک اسید و کوتریموکسازول در پیشگیری از عفونت ادراری راجعه با روش استفاده‌ی طولانی مدت با دوز کم

Introduction & Objective: Urinary tract infections (UTI) are a common cause of morbidity and its diagnosis and treatment can lead to health. In this study we evaluated the efficacy of the long- term low-dose antibiotic prophylaxis with Cotrimoxazole and Nalidixic-acid in the patients with recurrent UTI. Materials & Methods: This study is a before and after clinical trial without control grou...

متن کامل

Increasing antibiotic resistance among uropathogens isolated during years 2006-2009: impact on the empirical management.

UNLABELLED Urinary tract infections (UTI) are one of the most common infections with an increasing resistance to antimicrobial agents. PURPOSE Empirical initial antibiotic treatment of UTI must rely on susceptible data from local studies. MATERIALS AND METHODS Retrospective analysis of isolated bacteria from children with UTIs was performed at the university hospital during years 2006-2009....

متن کامل

بررسی میزان مقاومت به نالیدیکسیک اسید در سالمونلاهای تیفوئیدی و غیرتیفوئیدی جدا شده از بیماران بستری در یک دوره یکساله 85-1384

    Background & Aim: Nalidixic acid is a quinolone antibiotic with excellent in vitro and in vivo activity against salmonella. It is often the first choice for treating drug resistance salmonella infections. Nalidixic acid resistance can often lead to resistance to fluoroquinolones such as ciprofloxacin. In this survey the extent of salmonella infections, the salmonella strains involved, antib...

متن کامل

Drug-induced diabetes.

The only drugs which commonly cause diabetes during therapeutic use are the anti-hypertensive vasodilator diazoxide, and corticosteroids in high doses such as those used to palliate intracranial tumours. Thiazide diuretics have in the past been used in higher doses than necessary to treat hypertension, and the lower doses now used probably carry only a slight risk of inducing diabetes. The risk...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • British medical journal

دوره 2 6101  شماره 

صفحات  -

تاریخ انتشار 1977